{"id":11874,"date":"2023-09-10T16:45:40","date_gmt":"2023-09-10T20:45:40","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/?post_type=ccna_publication&p=11874"},"modified":"2025-03-03T16:45:57","modified_gmt":"2025-03-03T21:45:57","slug":"hla-in-isolated-rem-sleep-behavior-disorder-and-lewy-body-dementia","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/hla-in-isolated-rem-sleep-behavior-disorder-and-lewy-body-dementia\/","title":{"rendered":"HLA in isolated REM sleep behavior disorder and Lewy body dementia"},"content":{"rendered":"

Abstract<\/h2>\n

Synucleinopathies-related disorders such as Lewy body dementia (LBD) and isolated\/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA-DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27-1.93, p = 2.70e-05). We also discovered associations between iRBD and HLA-DRB1 70D (OR = 1.26, 95%CI = 1.12-1.41, p = 8.76e-05), 70Q (OR = 0.81, 95%CI = 0.72-0.91, p = 3.65e-04) and 71R (OR = 1.21, 95%CI = 1.08-1.35, p = 1.35e-03). Position 71 (pomnibus<\/sub>\u00a0= 0.00102) and 70 (pomnibus<\/sub>\u00a0= 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.<\/p>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-11874","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"\nHLA in isolated REM sleep behavior disorder and Lewy body dementia - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/hla-in-isolated-rem-sleep-behavior-disorder-and-lewy-body-dementia\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"HLA in isolated REM sleep behavior disorder and Lewy body dementia - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Synucleinopathies-related disorders such as Lewy body dementia (LBD) and ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/hla-in-isolated-rem-sleep-behavior-disorder-and-lewy-body-dementia\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - 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