{"id":12213,"date":"2023-04-17T09:59:37","date_gmt":"2023-04-17T13:59:37","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/?post_type=ccna_publication&#038;p=12213"},"modified":"2025-03-05T09:59:56","modified_gmt":"2025-03-05T14:59:56","slug":"subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls\/","title":{"rendered":"Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer&rsquo;s disease and controls"},"content":{"rendered":"<h2>Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\"><strong class=\"sub-title\">Background:\u00a0<\/strong>Previous reports have suggested that patients with cerebral amyloid angiopathy (CAA) may harbor smaller white matter, basal ganglia, and cerebellar volumes compared to age-matched healthy controls (HC) or patients with Alzheimer&rsquo;s disease (AD). We investigated whether CAA is associated with subcortical atrophy.<\/div>\n<div class=\"abstract-content selected\"><strong class=\"sub-title\">Methods:\u00a0<\/strong>The study was based on the multi-site Functional Assessment of Vascular Reactivity cohort and included 78 probable CAA (diagnosed according to the Boston criteria v2.0), 33 AD, and 70 HC. Cerebral and cerebellar volumes were extracted from brain 3D T1-weighted MRI using FreeSurfer (v6.0). Subcortical volumes, including total white matter, thalamus, basal ganglia, and cerebellum were reported as proportion (%) of estimated total intracranial volume. White matter integrity was quantified by the peak width of skeletonized mean diffusivity.<\/div>\n<div class=\"abstract-content selected\"><strong class=\"sub-title\">Results:\u00a0<\/strong>Participants in the CAA group were older (74.0 \u00b1 7.0, female 44%) than the AD (69.7 \u00b1 7.5, female 42%) and HC (68.8 \u00b1 7.8, female 69%) groups. CAA participants had the highest white matter hyperintensity volume and worse white matter integrity of the three groups. After adjusting for age, sex, and study site, CAA participants had smaller putamen volumes (mean differences, -0.024% of intracranial volume; 95% confidence intervals, -0.041% to -0.006%;\u00a0<i>p<\/i>\u00a0= 0.005) than the HCs but not AD participants (-0.003%; -0.024 to 0.018%;\u00a0<i>p<\/i>\u00a0= 0.94). Other subcortical volumes including subcortical white matter, thalamus, caudate, globus pallidus, cerebellar cortex or cerebellar white matter were comparable between all three groups.<\/div>\n<div class=\"abstract-content selected\"><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>In contrast to prior studies, we did not find substantial atrophy of subcortical volumes in CAA compared to AD or HCs, except for the putamen. Differences between studies may reflect heterogeneity in CAA presenting syndromes or severity.<\/div>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-12213","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer&#039;s disease and controls - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer&#039;s disease and controls - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Background:\u00a0Previous reports have suggested that patients with cerebral amyloid ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - CCNV\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-05T14:59:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/CCNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/subcortical-volumes-in-cerebral-amyloid-angiopathy-compared-with-alzheimers-disease-and-controls\/\",\"name\":\"Subcortical volumes in cerebral amyloid angiopathy compared with Alzheimer's disease and controls - 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