Introduction:\u00a0<\/strong>Cerebral amyloid angiopathy (CAA) is characterized by the deposition of beta-amyloid (A\u03b2) in small vessels leading to hemorrhagic stroke and dementia. This study examined whether plasma A\u03b242\/40<\/sub>, phosphorylated-tau (p-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) differ in CAA and their potential to discriminate Boston Criteria 2.0 probable CAA from healthy controls.<\/p>\n Methods:\u00a0<\/strong>Plasma A\u03b242\/40<\/sub>, p-tau-181, NfL, and GFAP were quantified using single molecule array (Simoa) and A\u03b242\/40<\/sub>\u00a0was also independently quantified using immunoprecipitation liquid chromatography mass-spectrometry (IPMS).<\/p>\n Results:\u00a0<\/strong>Forty-five participants with CAA and 47 healthy controls had available plasma. A\u03b242\/40<\/sub>\u00a0ratios were significantly lower in CAA than healthy controls. While p-tau-181 and NfL were elevated in CAA, GFAP was similar. A combination of A\u03b242\/40<\/sub>\u00a0(Simoa), p-tau-181, and NfL resulted in an area under the curve of 0.90 (95% confidence interval: 0.80, 0.95).<\/p>\n Discussion:\u00a0<\/strong>Plasma A\u03b242\/40<\/sub>, p-tau-181, and NfL differ in those with CAA and together can discriminate CAA from healthy controls.<\/p>\n Highlights:\u00a0<\/strong>Participants with CAA had reduced plasma A\u03b242\/40<\/sub>\u00a0ratios compared to controls. Plasma p-tau-181 and NfL concentrations are elevated in CAA compared to controls. Plasma GFAP was similar in CAA and controls. Together, plasma A\u03b242\/40<\/sub>, p-tau-181, and NfL had excellent discriminability for CAA.<\/p>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-13934","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"\n