{"id":13938,"date":"2025-05-14T21:17:07","date_gmt":"2025-05-15T01:17:07","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/?post_type=ccna_publication&#038;p=13938"},"modified":"2025-05-14T21:17:07","modified_gmt":"2025-05-15T01:17:07","slug":"two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment\/","title":{"rendered":"Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment"},"content":{"rendered":"<h2>Abstract<\/h2>\n<p>Cerebrovascular dysfunction, a risk factor for dementia, is challenging to detect in mild cognitive impairment (MCI). Herein, we used novel, light-based technology to investigate low-frequency hemodynamic oscillations (LFO; 0.02-0.16 Hz) in cerebral perfusion, oxygenation, and relative metabolic rate of oxygen (rCMRO<sub>2<\/sub>) in MCI (n = 13; 74 \u00b1 6 years) and cognitively-intact controls (CTL, n = 10; 69 \u00b1 6 years). Relative cerebral microvascular perfusion and tissue oxygenation changes were recorded using a depth-enhanced optical monitoring system. Continuous wavelet transforms were used to compare average LFO power between groups (\u03b1 = 0.025). Compared to controls, MCI had lower LFO power in microvascular perfusion, greater power in oxygenation (p \u2264 0.02), and no statistical difference in oscillatory power for rCMRO<sub>2<\/sub>.Similar rCMRO<sub>2<\/sub>\u00a0but opposing changes in oscillatory power for cerebral perfusion and oxygenation associated with MCI suggest an adaptation to maintain energy production.<\/p>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-13938","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Cerebrovascular dysfunction, a risk factor for dementia, is challenging ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - CCNV\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/CCNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/two-paths-to-one-destination-altered-low-frequency-oscillations-of-cerebral-perfusion-and-oxygenation-but-not-oxygen-metabolism-in-mild-cognitive-impairment\/\",\"name\":\"Two paths to one destination: Altered low-frequency oscillations of cerebral perfusion and oxygenation but not oxygen metabolism in mild cognitive impairment - 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