{"id":13992,"date":"2024-11-16T15:24:42","date_gmt":"2024-11-16T20:24:42","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/?post_type=ccna_publication&#038;p=13992"},"modified":"2025-05-16T15:24:54","modified_gmt":"2025-05-16T19:24:54","slug":"associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/","title":{"rendered":"Associated risk and resilience factors of Alzheimer&rsquo;s disease in women with early bilateral oophorectomy: Data from the UK Biobank"},"content":{"rendered":"<h2>Abstract<\/h2>\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Bilateral oophorectomy (BO) confers immediate estradiol loss. We examined prevalence and predictors of Alzheimer&rsquo;s disease (AD) in women with early BO comparing their odds ratios of AD to those of women with spontaneous menopause (SM).<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>A cohort from UK Biobank (n = 34,603) included women aged 60 + at baseline with and without AD who had early BO or SM. AD was determined based on AD related ICD-10 or ICD-9 code. We used logistic regression to model the association of menopause type with AD. Model predictors included age, education, age at menopause, hormone therapy (HT),\u00a0<i>APOE4<\/i>, body mass index (BMI), cancer history, and smoking history.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Those with early BO had four times the odds of developing AD (OR = 4.12, 95% CI [2.02, 8.44]) compared to those with SM.\u00a0<i>APOE4<\/i>\u00a0(OR = 4.29, 95% CI [2.43, 7.56]), and older age (OR = 1.16, 95% CI [1.05, 1.28]) were associated with increased odds of AD in the BO group. Greater years of education were associated with reduced odds of AD for both BO (OR = 0.91, 95% CI [0.85, 0.98]), and SM (OR = 0.95, 95% CI [0.90, 0.99]), while ever use of HT was associated with decreased odds of AD only for the BO group (OR = 0.43, 95% CI [0.23, 0.82]).<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Women with early BO, particularly with an\u00a0<i>APOE4<\/i>\u00a0allele, are at high risk of AD. Women with early BO who use HT and those with increased education have lower odds of developing AD.<\/p>\n","protected":false},"author":14,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[91,162],"class_list":["post-13992","ccna_publication","type-ccna_publication","status-publish","hentry","studies-relation-sexe-et-genre","studies-relation-wsgd-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Associated risk and resilience factors of Alzheimer&#039;s disease in women with early bilateral oophorectomy: Data from the UK Biobank - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Associated risk and resilience factors of Alzheimer&#039;s disease in women with early bilateral oophorectomy: Data from the UK Biobank - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Background:\u00a0Bilateral oophorectomy (BO) confers immediate estradiol loss. We examined ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - CCNV\" \/>\n<meta property=\"article:modified_time\" content=\"2025-05-16T19:24:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/CCNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/\",\"name\":\"Associated risk and resilience factors of Alzheimer's disease in women with early bilateral oophorectomy: Data from the UK Biobank - CCNA - CCNV\",\"isPartOf\":{\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#website\"},\"datePublished\":\"2024-11-16T20:24:42+00:00\",\"dateModified\":\"2025-05-16T19:24:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/#breadcrumb\"},\"inLanguage\":\"fr-CA\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/ccna-ccnv.ca\/fr\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Associated risk and resilience factors of Alzheimer&#8217;s disease in women with early bilateral oophorectomy: Data from the UK Biobank\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#website\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/\",\"name\":\"Canadian Consortium on Neurodegeneration in Aging\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#organization\"},\"alternateName\":\"CCNA - CCNV\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ccna-ccnv.ca\/fr\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-CA\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#organization\",\"name\":\"Canadian Consortium on Neurodegeneration in Aging\",\"alternateName\":\"CCNA - CCNV\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-CA\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/ccna-logo-on-white-background.jpg\",\"contentUrl\":\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/ccna-logo-on-white-background.jpg\",\"width\":696,\"height\":696,\"caption\":\"Canadian Consortium on Neurodegeneration in Aging\"},\"image\":{\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Associated risk and resilience factors of Alzheimer's disease in women with early bilateral oophorectomy: Data from the UK Biobank - CCNA - CCNV","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/associated-risk-and-resilience-factors-of-alzheimers-disease-in-women-with-early-bilateral-oophorectomy-data-from-the-uk-biobank\/","og_locale":"fr_CA","og_type":"article","og_title":"Associated risk and resilience factors of Alzheimer's disease in women with early bilateral oophorectomy: Data from the UK Biobank - CCNA - CCNV","og_description":"Abstract Background:\u00a0Bilateral oophorectomy (BO) confers immediate estradiol loss. 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