{"id":4046,"date":"2015-09-30T01:11:28","date_gmt":"2015-09-30T05:11:28","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/determining-composition-micron-scale-protein-deposits-neurodegenerative-disease-spatially-targeted-optical-microproteomics-elife-20154-2\/"},"modified":"2024-12-03T12:02:59","modified_gmt":"2024-12-03T17:02:59","slug":"determining-composition-micron-scale-protein-deposits-neurodegenerative-disease-spatially-targeted-optical-microproteomics-elife-20154-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/determining-composition-micron-scale-protein-deposits-neurodegenerative-disease-spatially-targeted-optical-microproteomics-elife-20154-2\/","title":{"rendered":"Determining composition of micron-scale protein deposits in neurodegenerative disease by spatially targeted optical microproteomics."},"content":{"rendered":"<p>R\u00c9SUM\u00c9 SIMPLIFI\u00c9<\/p>\n<p>Dans de nombreuses maladies neurod\u00e9g\u00e9n\u00e9ratives \u2014 y compris la maladie d\u2019Alzheimer \u2014 les d\u00e9p\u00f4ts de prot\u00e9ines mal repli\u00e9es se forment dans le cerveau. Bien qu\u2019ils soient visibles au microscope, ces d\u00e9p\u00f4ts sont trop petits pour \u00eatre isol\u00e9s et extraits. Dans cet article, les chercheurs d\u00e9montrent comment leur nouvelle technique \u2014 la microprot\u00e9omique optique cibl\u00e9e spatialement (STOMP) \u2014 utilise une lumi\u00e8re laser tr\u00e8s concentr\u00e9e pour fixer des poign\u00e9es chimiques \u00e0 ces d\u00e9p\u00f4ts prot\u00e9iques, de sorte qu\u2019ils puissent \u00eatre r\u00e9cup\u00e9r\u00e9s pour fins d\u2019identification et d\u2019analyse. \u00c0 l\u2019aide de la STOMP, les chercheurs ont identifi\u00e9 un certain nombre de prot\u00e9ines qui n\u2019avaient pas \u00e9t\u00e9 associ\u00e9es \u00e0 la pathologie de la maladie d\u2019Alzheimer auparavant (y compris certaines prot\u00e9ines impliqu\u00e9es dans la signalisation \u00e0 travers les synapses, entre les neurones) et esp\u00e8rent voir la technologie STOMP utilis\u00e9e pour explorer la biologie sous-jacente \u00e0 d\u2019autres maladies neurod\u00e9g\u00e9n\u00e9ratives.<\/p>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4046","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - 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