{"id":4064,"date":"2019-11-12T15:38:53","date_gmt":"2019-11-12T20:38:53","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis\/"},"modified":"2024-12-03T12:27:53","modified_gmt":"2024-12-03T17:27:53","slug":"resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis\/","title":{"rendered":"Resting-state network dysfunction in Alzheimer’s disease: A systematic review and meta-analysis."},"content":{"rendered":"

R\u00c9SUM\u00c9<\/p>\n

INTRODUCTION: We performed a systematic review and\u00a0meta-analysis\u00a0of the\u00a0Alzheimer’s disease\u00a0(AD) literature to examine\u00a0consistency of\u00a0functional connectivity\u00a0alterations in AD\u00a0dementia\u00a0and\u00a0mild cognitive impairment, using resting-state\u00a0functional magnetic resonance imaging.<\/p>\n

METHODS: Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.<\/p>\n

RESULTS:\u00a0Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and\u00a0limbic\u00a0networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the\u00a0default mode network.<\/p>\n

\n

DISCUSSION: Convergent evidence across the literature supports the use of resting-state connectivity as a\u00a0biomarker\u00a0of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4064","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"\nResting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis. - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis. - 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