{"id":4078,"date":"2018-04-26T21:14:59","date_gmt":"2018-04-27T01:14:59","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/14540\/"},"modified":"2024-12-03T13:20:06","modified_gmt":"2024-12-03T18:20:06","slug":"14540","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/14540\/","title":{"rendered":"FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-\u03c0 Interactions"},"content":{"rendered":"<p><strong>R\u00c9SUM\u00c9 SIMPLIFI\u00c9<\/strong><\/p>\n<p>Une prot\u00e9ine appel\u00e9e FUS est impliqu\u00e9e dans plusieurs r\u00e9actions biochimiques importantes \u00e0 l\u2019int\u00e9rieur des cellules humaines, dont la synth\u00e8se de nouvelles prot\u00e9ines \u00e0 partir du mat\u00e9riel g\u00e9n\u00e9tique. FUS peut se pr\u00e9senter sous diff\u00e9rentes formes. Elle peut \u00eatre enti\u00e8rement dissoute, se pr\u00e9senter sous forme de gouttelettes de prot\u00e9ines s\u00e9par\u00e9es en deux phases (comme un m\u00e9lange d\u2019huile et de vinaigre), ou sous forme d\u2019hydrogel s\u00e9par\u00e9 en deux phases (comme des petits morceaux de gel\u00e9e flottant dans un liquide). Ces diff\u00e9rents \u00e9tats physiques jouent un r\u00f4le essentiel dans les processus cellulaires impliquant FUS car lorsque ceux-ci sont d\u00e9r\u00e9gl\u00e9s ils peuvent causer certaines maladies comme la d\u00e9g\u00e9n\u00e9rescence lobaire fronto-temporale (DLFT). Par cons\u00e9quent, une meilleure compr\u00e9hension des facteurs cellulaires et mol\u00e9culaires qui contr\u00f4lent le passage de la prot\u00e9ine FUS d\u2019un \u00e9tat physique \u00e0 l\u2019autre (une transition nomm\u00e9e s\u00e9paration de phase) serait un atout pr\u00e9cieux et pourrait conduire \u00e0 de nouvelles avenues de recherche en vue d\u2019interventions th\u00e9rapeutiques pour la DLFT.<\/p>\n<p>Dans cette \u00e9tude financ\u00e9e en partie par le CCNV et dirig\u00e9e par le Dr Peter St George-Hyslop et son \u00e9quipe, en collaboration avec plusieurs chercheurs du Royaume-Uni, d\u2019Espagne et des \u00c9tats-Unis, les chercheurs ont mis au jour plusieurs \u00e9l\u00e9ments cl\u00e9s dans la s\u00e9paration de phase de la prot\u00e9ine FUS. Ils ont reconstitu\u00e9 en laboratoire et manipul\u00e9 les \u00e9tapes importantes du processus de s\u00e9paration et ont utilis\u00e9 la technique de spectroscopie nano-infrarouge \u00e0 force atomique pour visualiser l\u2019\u00e9tat de la prot\u00e9ine. Ils ont ainsi d\u00e9couvert que la s\u00e9paration de phase de la prot\u00e9ine FUS est tr\u00e8s \u00e9troitement r\u00e9gul\u00e9e par la structure chimique de certains des acides amin\u00e9s composant la prot\u00e9ine. Les chercheurs ont aussi r\u00e9v\u00e9l\u00e9 le r\u00f4le d\u2019une autre prot\u00e9ine, appel\u00e9e TNPO1 qui, dans certains cas, semble ne pas fonctionner normalement. Lorsque ces processus sont d\u00e9r\u00e9gl\u00e9s, la prot\u00e9ine FUS se condense de fa\u00e7on irr\u00e9versible sous forme d\u2019hydrogel dans les neurones, ce qui r\u00e9sulte en un arr\u00eat de la synth\u00e8se de nouvelles prot\u00e9ines dans les synapses (connexions entre les cellules nerveuses).<\/p>\n<p>Ces r\u00e9sultats sont importants parce qu\u2019ils offrent des indices sur les causes de l\u2019accumulation de la prot\u00e9ine FUS dans certaines neurones observ\u00e9e dans la DLFT. De plus, plusieurs des m\u00e9thodes d\u00e9velopp\u00e9es pour cette \u00e9tude seront tr\u00e8s utiles pour les recherches futures sur la s\u00e9paration de phase de la prot\u00e9ine FUS et son effet sur la DLFT, et sur de nouveaux traitements ou modes de pr\u00e9vention de ces maladies actuellement incurables.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4078","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-\u03c0 Interactions - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/14540\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-\u03c0 Interactions - 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