{"id":4337,"date":"2017-01-02T02:05:41","date_gmt":"2017-01-02T07:05:41","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis-alzheimers-873-85-2\/"},"modified":"2024-12-03T11:59:46","modified_gmt":"2024-12-03T16:59:46","slug":"resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis-alzheimers-873-85-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis-alzheimers-873-85-2\/","title":{"rendered":"Resting-state network dysfunction in Alzheimer’s disease: A systematic review and meta-analysis"},"content":{"rendered":"

ABSTRACT<\/strong><\/p>\n

INTRODUCTION: We performed a systematic review and\u00a0meta-analysis<\/a>\u00a0of the\u00a0Alzheimer’s disease<\/a>\u00a0(AD) literature to examine consistency of\u00a0functional connectivity<\/a>\u00a0alterations in AD\u00a0dementia<\/a>\u00a0and\u00a0mild cognitive impairment<\/a>, using resting-state\u00a0functional magnetic resonance imaging<\/a>.<\/p>\n

METHODS: Studies were screened using a standardized procedure. Multiresolution statistics were performed to assess the spatial consistency of findings across studies.<\/p>\n

RESULTS: Thirty-four studies were included (1363 participants, average 40 per study). Consistent alterations in connectivity were found in the default mode, salience, and\u00a0limbic<\/a>\u00a0networks in patients with AD dementia, mild cognitive impairment, or in both groups. We also identified a strong tendency in the literature toward specific examination of the\u00a0default mode network<\/a>.<\/p>\n

\n

DISCUSSION: Convergent evidence across the literature supports the use of resting-state connectivity as a\u00a0biomarker<\/a>\u00a0of AD. The locations of consistent alterations suggest that highly connected hub regions in the brain might be an early target of AD.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4337","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"\nResting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/resting-state-network-dysfunction-alzheimers-disease-systematic-review-meta-analysis-alzheimers-873-85-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis - 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