{"id":4587,"date":"2020-06-22T18:14:58","date_gmt":"2020-06-22T22:14:58","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/neural-basis-of-long-term-musical-memory-in-cognitively-impaired-older-persons-2\/"},"modified":"2024-12-03T14:57:06","modified_gmt":"2024-12-03T19:57:06","slug":"neural-basis-of-long-term-musical-memory-in-cognitively-impaired-older-persons-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/neural-basis-of-long-term-musical-memory-in-cognitively-impaired-older-persons-2\/","title":{"rendered":"Neural basis of long-term musical memory in cognitively impaired older persons"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"en-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>The objective of this study was to determine whether exposure to long-known music would evoke more extensive activation of brain regions minimally affected by Alzheimer disease (AD) pathology and outside traditional memory networks using a functional magnetic resonance imaging paradigm involving listening to long-known and recently-learned music in older adults with cognitive impairment to provide insight into mechanisms of long-term musical memory preservation in cognitively impaired older persons.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>Seventeen subjects with a diagnosis of mild AD or mild cognitive impairment were recruited for this study. Subjects were scanned using functional magnetic resonance imaging while they performed a music listening task, which included short clips of personally selected music from the patient&rsquo;s past and newly-composed music heard for the first time 60 minutes before scanning. From this task, we obtained group-level maps comparing brain areas associated with long-known and recently-heard music in all subjects.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Exposure to long-known music preferentially activated brain regions including the medial prefrontal cortex, precuneus, anterior insula, basal ganglia, hippocampus, amygdala, and cerebellum relative to recently-heard music. These areas are involved in autobiographical memory and associated emotional responses. In addition, they are minimally affected by early stage AD pathology, thus providing a neural basis for long-known musical memory survival.<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Long-known music activates a bilateral network of prefrontal, emotional, motor, auditory, and subcortical regions (cerebellum, putamen, limbic structures). This extensive activation, relative to recently-heard music, may offer structural and functional clues as to why long-term musical memory appears to be relatively preserved among cognitively impaired older persons.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4587","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neural basis of long-term musical memory in cognitively impaired older persons - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/neural-basis-of-long-term-musical-memory-in-cognitively-impaired-older-persons-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neural basis of long-term musical memory in cognitively impaired older persons - 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