{"id":4635,"date":"2020-09-28T20:42:36","date_gmt":"2020-09-29T00:42:36","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-individuals-2\/"},"modified":"2024-12-03T14:57:14","modified_gmt":"2024-12-03T19:57:14","slug":"plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-individuals-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-individuals-2\/","title":{"rendered":"Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired Individuals"},"content":{"rendered":"<div class=\"align-m\">\n<h2>Abstract<\/h2>\n<\/div>\n<div class=\"collapsable-text readability is-active\">\n<p><strong>Background<\/strong><\/p>\n<p>Alzheimer\u2019s disease (AD) biomarkers are primarily evaluated through MRI, PET, and CSF methods in order to diagnose and monitor disease. Recently, advances in the assessment of blood-based biomarkers have shown promise for simple, inexpensive, accessible, and minimally invasive tools with diagnostic and prognostic value for AD. Most recently, plasma phosphorylated tau181 (p-tau181) has shown excellent performance. The relationship between plasma p-tau181 and cerebral metabolic dysfunction assessed by [<sup>18<\/sup>F]FDG PET in AD is still unknown.<\/p>\n<p><strong>Methods<\/strong><\/p>\n<p>This study was performed on a total of 892 individuals (297 cognitively unimpaired; 595 cognitively impaired) from the ADNI cohort. Plasma p-tau181 was assessed using single molecular array (Simoa) technology and metabolic dysfunction was indexed by [<sup>18<\/sup>F]FDG PET. Cross-sectional associations between plasma and CSF p-tau181 and [<sup>18<\/sup>F]FDG were assessed using voxelwise linear regression models, with individuals stratified by diagnostic group and by A\u03b2 status. Associations between baseline plasma p-tau181 and longitudinal rate of brain metabolic decline were also assessed in a subset (n=389) of individuals using correlations and voxelwise regression models.<\/p>\n<p><strong>Results<\/strong><\/p>\n<p>Plasma p-tau181 was elevated in A\u03b2+ and cognitively impaired individuals as well as in\u00a0<em>APOE\u00a0<\/em>\u03b54 carriers, and was significantly associated with age, worse cognitive performance, and CSF p-tau181. Cross-sectional analyses showed strong associations between plasma p-tau181 and [<sup>18<\/sup>F]FDG PET in A\u03b2+ and cognitively impaired individuals. Voxelwise longitudinal analyses showed that baseline plasma p-tau181 concentrations were significantly associated with annual rates of metabolic decline only in cognitively impaired individuals, bilaterally in the medial and lateral temporal lobes.<\/p>\n<p><strong>Conclusions<\/strong><\/p>\n<p>The associations between plasma p-tau181 and reduced brain metabolism, primarily in cognitively impaired and in A\u03b2+ individuals, supports the use of plasma p-tau181 as a simple, low-cost, minimally invasive, and accessible tool to both assess current and predict future metabolic dysfunction associated with AD, comparatively to PET, MRI, and CSF methods.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4635","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired Individuals - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-individuals-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired Individuals - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Background Alzheimer\u2019s disease (AD) biomarkers are primarily evaluated through ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-individuals-2\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - 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