{"id":4655,"date":"2020-10-30T18:37:10","date_gmt":"2020-10-30T22:37:10","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/topographical-distribution-of-amyloid-%ce%b2-tau-and-atrophy-in-behavioral-dysexecutive-ad-patients-2\/"},"modified":"2024-12-03T14:57:17","modified_gmt":"2024-12-03T19:57:17","slug":"topographical-distribution-of-amyloid-%ce%b2-tau-and-atrophy-in-behavioral-dysexecutive-ad-patients-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/topographical-distribution-of-amyloid-%ce%b2-tau-and-atrophy-in-behavioral-dysexecutive-ad-patients-2\/","title":{"rendered":"Topographical distribution of amyloid-\u03b2, tau and atrophy in behavioral \/ dysexecutive AD patients"},"content":{"rendered":"<h2>Abstract<\/h2>\n<div id=\"sec-1\" class=\"subsection\">\n<p id=\"p-758\"><strong>Objective<\/strong>\u00a0To determine the associations between amyloid-PET, tau-PET and atrophy with the behavioural\/dysexecutive presentation of Alzheimer&rsquo;s disease (AD), how these differ from amnestic AD, and how they correlate to clinical symptoms.<\/p>\n<\/div>\n<div id=\"sec-2\" class=\"subsection\">\n<p id=\"p-759\"><strong>Methods<\/strong>\u00a0We assessed 15 cases of behavioural\/dysexecutive AD recruited from a tertiary care memory clinic, all of whom had biologically defined AD. They were compared with 25 disease severity- and age-matched amnestic AD patients and a group of 131 cognitively unimpaired (CU) elderly individuals. All subjects were evaluated with amyloid-PET with [<sup>18<\/sup>F]AZD4694, tau-PET with [<sup>18<\/sup>F]MK6240, MRI and neuropsychological testing.<\/p>\n<\/div>\n<div id=\"sec-3\" class=\"subsection\">\n<p id=\"p-760\"><strong>Results<\/strong>\u00a0Voxelwise contrasts identified patterns of frontal cortical tau aggregation in behavioural\/dysexecutive AD, with peaks in medial prefrontal, anterior cingulate and frontal insular cortices in contrast to amnestic AD. No differences were observed in the distribution of amyloid-PET or atrophy as determined by voxel-based morphometry. Voxelwise area under the ROC curve analyses revealed that tau-PET uptake in the medial prefrontal, anterior cingulate and frontal insular cortices were best able to differentiate between behavioural\/dysexecutive and amnestic AD (AUC = 0.87). Voxelwise regressions demonstrated relationships between frontal cortical tau load and degree of executive dysfunction.<\/p>\n<\/div>\n<div id=\"sec-4\" class=\"subsection\">\n<p id=\"p-761\"><strong>Conclusions<\/strong>\u00a0Our results provide evidence of frontal cortical involvement of tau pathology in behavioural\/dysexecutive AD and highlight the need for consensus clinical criteria in this syndrome.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4655","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Topographical distribution of amyloid-\u03b2, tau and atrophy in behavioral \/ dysexecutive AD patients - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/topographical-distribution-of-amyloid-%ce%b2-tau-and-atrophy-in-behavioral-dysexecutive-ad-patients-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Topographical distribution of amyloid-\u03b2, tau and atrophy in behavioral \/ dysexecutive AD patients - 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