{"id":4661,"date":"2020-11-12T17:01:40","date_gmt":"2020-11-12T22:01:40","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/a-new-role-for-matrix-metalloproteinase-3-in-the-ngf-metabolic-pathway-proteolysis-of-mature-ngf-and-sex-specific-differences-in-the-continuum-of-alzheimers-pathology-2\/"},"modified":"2024-12-03T14:57:18","modified_gmt":"2024-12-03T19:57:18","slug":"a-new-role-for-matrix-metalloproteinase-3-in-the-ngf-metabolic-pathway-proteolysis-of-mature-ngf-and-sex-specific-differences-in-the-continuum-of-alzheimers-pathology-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/a-new-role-for-matrix-metalloproteinase-3-in-the-ngf-metabolic-pathway-proteolysis-of-mature-ngf-and-sex-specific-differences-in-the-continuum-of-alzheimers-pathology-2\/","title":{"rendered":"A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer&rsquo;s pathology"},"content":{"rendered":"<h2 class=\"section-title u-h3 u-margin-l-top u-margin-xs-bottom\">Abstract<\/h2>\n<div id=\"as0005\">\n<p id=\"sp0055\">Matrix metalloproteinase-3 (MMP-3) has been associated with risk of Alzheimer&rsquo;s disease (AD). In this study we introduce a novel role for MMP-3 in degrading nerve growth factor (NGF) in vivo and examine its mRNA and protein expression across the continuum of AD pathology. We provide evidence that MMP-3 participates in the degradation of mature NGF in vitro and in vivo and that it is secreted from the rat cerebral cortex in an activity-dependent manner. We show that cortical MMP-3 is upregulated in the McGill-R-Thy1-APP transgenic rat model of AD-like amyloidosis. A similar upregulation was found in AD and MCI brains as well as in cognitively normal individuals with elevated amyloid deposition. We also observed that frontal cortex MMP-3 protein levels are higher in males. MMP-3 protein correlated with more AD neuropathology, markers of NGF metabolism, and lower cognitive scores in males but not in females. These results suggest that MMP-3 upregulation in AD might contribute to NGF dysmetabolism, and therefore to cholinergic atrophy and cognitive deficits, in a sex-specific manner. MMP-3 should be further investigated as a biomarker candidate or as a therapeutic target in AD.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[91],"class_list":["post-4661","ccna_publication","type-ccna_publication","status-publish","hentry","studies-relation-sexe-et-genre"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer&#039;s pathology - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/a-new-role-for-matrix-metalloproteinase-3-in-the-ngf-metabolic-pathway-proteolysis-of-mature-ngf-and-sex-specific-differences-in-the-continuum-of-alzheimers-pathology-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new role for matrix metalloproteinase-3 in the NGF metabolic pathway: Proteolysis of mature NGF and sex-specific differences in the continuum of Alzheimer&#039;s pathology - 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