{"id":4684,"date":"2020-12-23T18:56:09","date_gmt":"2020-12-23T23:56:09","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/comprehensive-analysis-of-familial-parkinsonism-genes-in-rapid-eye-movement-sleep-behavior-disorder-2\/"},"modified":"2024-12-03T14:57:22","modified_gmt":"2024-12-03T19:57:22","slug":"comprehensive-analysis-of-familial-parkinsonism-genes-in-rapid-eye-movement-sleep-behavior-disorder-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/comprehensive-analysis-of-familial-parkinsonism-genes-in-rapid-eye-movement-sleep-behavior-disorder-2\/","title":{"rendered":"Comprehensive Analysis of Familial Parkinsonism Genes in Rapid-Eye-Movement Sleep Behavior Disorder"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>There is only partial overlap in the genetic background of isolated rapid-eye-movement sleep behavior disorder (iRBD) and Parkinson&rsquo;s disease (PD).<\/p>\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>To examine the role of autosomal dominant and recessive PD or atypical parkinsonism genes in the risk of iRBD.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>Ten genes, comprising the recessive genes PRKN, DJ-1 (PARK7), PINK1, VPS13C, ATP13A2, FBXO7, and PLA2G6 and the dominant genes LRRK2, GCH1, and VPS35, were fully sequenced in 1039 iRBD patients and 1852 controls of European ancestry, followed by association tests.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>We found no association between rare heterozygous variants in the tested genes and risk of iRBD. Several homozygous and compound heterozygous carriers were identified, yet there was no overrepresentation in iRBD patients versus controls.<\/p>\n<p><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>Our results do not support a major role for variants in these genes in the risk of iRBD.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4684","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Comprehensive Analysis of Familial Parkinsonism Genes in Rapid-Eye-Movement Sleep Behavior Disorder - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/comprehensive-analysis-of-familial-parkinsonism-genes-in-rapid-eye-movement-sleep-behavior-disorder-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comprehensive Analysis of Familial Parkinsonism Genes in Rapid-Eye-Movement Sleep Behavior Disorder - 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