{"id":4746,"date":"2021-04-14T19:05:50","date_gmt":"2021-04-14T23:05:50","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/white-matter-hyperintensities-mediate-the-impact-of-amyloid-s-on-future-freezing-of-gait-in-parkinsons-disease-2\/"},"modified":"2024-12-03T14:57:33","modified_gmt":"2024-12-03T19:57:33","slug":"white-matter-hyperintensities-mediate-the-impact-of-amyloid-s-on-future-freezing-of-gait-in-parkinsons-disease-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/white-matter-hyperintensities-mediate-the-impact-of-amyloid-s-on-future-freezing-of-gait-in-parkinsons-disease-2\/","title":{"rendered":"White matter hyperintensities mediate the impact of amyloid \u00df on future freezing of gait in Parkinson\u2019s disease"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Freezing of gait (FOG) is a common symptom in Parkinson&rsquo;s Disease (PD) patients. Previous studies have reported relationships between FOG, substantia nigra (SN) degeneration, dopamine transporter (DAT) concentration, as well as amyloid \u03b2 deposition. However, there is a paucity of research on the concurrent impact of white matter damage.<\/p>\n<p><strong class=\"sub-title\">Objectives:\u00a0<\/strong>To assess the inter-relationships between these different co-morbidities, their impact on future FOG and whether they act independently of each other.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>We used baseline MRI and longitudinal gait data from 423 de novo PD patients from the Parkinson&rsquo;s Progression Markers Initiative (PPMI). We used deformation based morphometry (DBM) from T1-weighted MRI to measure SN atrophy, and segmentation of white matter hyperintensities (WMH) as a measure of WM pathological load. Putamen and caudate DAT levels from SPECT as well as cerebrospinal fluid (CSF) amyloid \u03b2 were obtained directly from the PPMI. Following correlation analyses, we investigated whether WMH burden mediates the impact of amyloid \u03b2 on future FOG.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>SN DBM, WMH load, putamen and caudate DAT activity and CSF amyloid \u03b2 levels were significantly different between PD patients with and without future FOG (p &lt; 0.008). Mediation analysis demonstrated an effect of CSF amyloid \u03b2 levels on future FOG via WMH load, independent of SN atrophy and striatal DAT activity levels.<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Amyloid \u03b2 might impact future FOG in PD patients through an increase in WMH burden, in a pathway independent of Lewy body pathology.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4746","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>White matter hyperintensities mediate the impact of amyloid \u00df on future freezing of gait in Parkinson\u2019s disease - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/white-matter-hyperintensities-mediate-the-impact-of-amyloid-s-on-future-freezing-of-gait-in-parkinsons-disease-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"White matter hyperintensities mediate the impact of amyloid \u00df on future freezing of gait in Parkinson\u2019s disease - 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