{"id":4748,"date":"2021-04-14T19:12:01","date_gmt":"2021-04-14T23:12:01","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/evidence-of-a-relation-between-hippocampal-volume-white-matter-hyperintensities-and-cognition-in-subjective-cognitive-decline-and-mild-cognitive-impairment-2\/"},"modified":"2024-12-03T14:57:33","modified_gmt":"2024-12-03T19:57:33","slug":"evidence-of-a-relation-between-hippocampal-volume-white-matter-hyperintensities-and-cognition-in-subjective-cognitive-decline-and-mild-cognitive-impairment-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/evidence-of-a-relation-between-hippocampal-volume-white-matter-hyperintensities-and-cognition-in-subjective-cognitive-decline-and-mild-cognitive-impairment-2\/","title":{"rendered":"Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>The concepts of mild cognitive impairment (MCI) and subjective cognitive decline (SCD) have been proposed to identify individuals in the early stages of Alzheimer&rsquo;s disease (AD), or other neurodegenerative diseases. One approach to validate these concepts is to investigate the relationship between pathological brain markers and cognition in those individuals.<\/p>\n<p><strong class=\"sub-title\">Method:\u00a0<\/strong>We included 126 participants from the Consortium for the Early Identification of Alzheimer&rsquo;s disease-Quebec (CIMA-Q) cohort (67 SCD, 29 MCI, and 30 cognitively healthy controls [CH]). All participants underwent a complete cognitive assessment and structural magnetic resonance imaging. Group comparisons were done using cognitive data, and then correlated with hippocampal volumes and white matter hyperintensities (WMHs).<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Significant differences were found between participants with MCI and CH on episodic and executive tasks, but no differences were found when comparing SCD and CH. Scores on episodic memory tests correlated with hippocampal volumes in both MCI and SCD, whereas performance on executive tests correlated with WMH in all of our groups.<\/p>\n<p><strong class=\"sub-title\">Discussion:\u00a0<\/strong>As expected, the SCD group was shown to be cognitively healthy on tasks where MCI participants showed impairment. However, SCD&rsquo;s hippocampal volume related to episodic memory performances, and WMH to executive functions. Thus, SCD represents a valid research concept and should be used, alongside MCI, to better understand the preclinical\/prodromal phase of AD.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4748","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/evidence-of-a-relation-between-hippocampal-volume-white-matter-hyperintensities-and-cognition-in-subjective-cognitive-decline-and-mild-cognitive-impairment-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evidence of a relation between hippocampal volume, white matter hyperintensities, and cognition in subjective cognitive decline and mild cognitive impairment - 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