{"id":4758,"date":"2021-04-14T19:24:09","date_gmt":"2021-04-14T23:24:09","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/neuropathologic-burden-and-the-degree-of-frailty-in-relation-to-global-cognition-and-dementia-2\/"},"modified":"2024-12-03T14:57:35","modified_gmt":"2024-12-03T19:57:35","slug":"neuropathologic-burden-and-the-degree-of-frailty-in-relation-to-global-cognition-and-dementia-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/neuropathologic-burden-and-the-degree-of-frailty-in-relation-to-global-cognition-and-dementia-2\/","title":{"rendered":"Neuropathologic burden and the degree of frailty in relation to global cognition and dementia"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>To test the hypothesis that degree of frailty and neuropathologic burden independently contribute to global cognition and odds of dementia.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>This was a secondary analysis of a prospective cohort study of older adults living in Illinois. Participants underwent an annual neuropsychological and clinical evaluation. We included 625 participants (mean age 89.7 \u00b1 6.1 years; 67.5% female) who died and underwent autopsy. We quantified neuropathology using an index measure of 10 neuropathologic features: \u03b2-amyloid deposition, hippocampal sclerosis, Lewy bodies, tangle density, TDP-43, cerebral amyloid angiopathy, arteriolosclerosis, atherosclerosis, and gross and chronic cerebral infarcts. Clinical consensus determined dementia status, which we coded as no cognitive impairment, mild cognitive impairment, or dementia. A battery of 19 tests spanning multiple domains quantified global cognition. We operationalized frailty using a 41-item frailty index. We employed regression analyses to model relationships between neuropathology, frailty, and dementia.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Both frailty and a neuropathology index were independently associated with global cognition and dementia status. These results held after controlling for traditional pathologic measures in a sample of participants with Alzheimer clinical syndrome. Frailty improved the fit of the model for dementia status (\u03c7<sup>2<\/sup>[2] 72.64;\u00a0<i>p<\/i>\u00a0&lt; 0.0001) and explained an additional 11%-12% of the variance in the outcomes.<\/p>\n<p><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>Dementia is a multiply determined condition, to which both general health, as captured by frailty, and neuropathology significantly contribute. This integrative view of dementia and health has implications for prevention and therapy; specifically, future research should evaluate frailty as a means of dementia risk reduction.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4758","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuropathologic burden and the degree of frailty in relation to global cognition and dementia - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/neuropathologic-burden-and-the-degree-of-frailty-in-relation-to-global-cognition-and-dementia-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuropathologic burden and the degree of frailty in relation to global cognition and dementia - 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