{"id":4799,"date":"2021-04-16T14:39:50","date_gmt":"2021-04-16T18:39:50","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/topographical-distribution-of-a%ce%b2-predicts-progression-to-dementia-in-a%ce%b2-positive-mild-cognitive-impairment-2\/"},"modified":"2024-12-03T14:57:41","modified_gmt":"2024-12-03T19:57:41","slug":"topographical-distribution-of-a%ce%b2-predicts-progression-to-dementia-in-a%ce%b2-positive-mild-cognitive-impairment-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/topographical-distribution-of-a%ce%b2-predicts-progression-to-dementia-in-a%ce%b2-positive-mild-cognitive-impairment-2\/","title":{"rendered":"Topographical distribution of A\u03b2 predicts progression to dementia in A\u03b2 positive mild cognitive impairment"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Introduction:\u00a0<\/strong>Abnormal brain amyloid beta (A\u03b2) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of A\u03b2 pathology can provide additional information to identify, among global A\u03b2 positive individuals, those destined for dementia.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>We studied 260 amnestic mild cognitive impairment (MCI) subjects who were A\u03b2-PET positive with [<sup>18<\/sup>F]florbetapir. Using [<sup>18<\/sup>F]florbetapir, we assessed the percentage of voxels sowing A\u03b2 abnormality as well as the standardized uptake value ratio (SUVR) values across brain regions. Regressions tested the predictive effect of A\u03b2 on progression to dementia over 2 years.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Neither global nor regional [<sup>18<\/sup>F]florbetapir SUVR concentrations predicted progression to dementia. In contrast, the spatial extent of A\u03b2 pathology in regions comprising the default mode network was highly associated with the development of dementia over 2 years.<\/p>\n<p><strong class=\"sub-title\">Discussion:\u00a0<\/strong>These results highlight that the regional distribution of A\u03b2 abnormality may provide important complementary information at an individual level regarding the likelihood of A\u03b2 positive MCI to progress to dementia.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4799","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Topographical distribution of A\u03b2 predicts progression to dementia in A\u03b2 positive mild cognitive impairment - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/topographical-distribution-of-a%ce%b2-predicts-progression-to-dementia-in-a%ce%b2-positive-mild-cognitive-impairment-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Topographical distribution of A\u03b2 predicts progression to dementia in A\u03b2 positive mild cognitive impairment - 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