{"id":4801,"date":"2021-04-27T20:30:15","date_gmt":"2021-04-28T00:30:15","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-and-amyloid-positive-individuals-2\/"},"modified":"2024-12-03T14:57:41","modified_gmt":"2024-12-03T19:57:41","slug":"plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-and-amyloid-positive-individuals-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-and-amyloid-positive-individuals-2\/","title":{"rendered":"Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired and Amyloid-Positive Individuals"},"content":{"rendered":"<h2 id=\"235400994\" class=\"abstract-title js-splitscreen-abstract-title\">Abstract<\/h2>\n<section class=\"abstract\">\n<p class=\"chapter-para\">Alzheimer\u2019s disease biomarkers are primarily evaluated through MRI, PET, and CSF methods in order to diagnose and monitor disease. Recently, advances in the assessment of blood-based biomarkers have shown promise for simple, inexpensive, accessible, and minimally invasive tools with diagnostic and prognostic value for Alzheimer\u2019s disease. Most recently, plasma phosphorylated tau181 has shown excellent performance. The relationship between plasma phosphorylated tau181 and cerebral metabolic dysfunction assessed by [18F]fluorodeoxyglucose (FDG) PET in Alzheimer\u2019s disease is still unknown. This study was performed on 892 older individuals (297 cognitively unimpaired; 595 cognitively impaired) from the Alzheimer\u2019s Disease Neuroimaging Initiative cohort. Plasma phosphorylated tau181 was assessed using single molecular array technology and metabolic dysfunction was indexed by [18F]FDG PET. Cross-sectional associations between plasma and CSF phosphorylated tau181 and [18F]FDG were assessed using voxelwise linear regression models, with individuals stratified by diagnostic group and by \u03b2-amyloid status. Associations between baseline plasma phosphorylated tau181 and longitudinal (24\u2009months) rate of brain metabolic decline were also assessed in 389 individuals with available data using correlations and voxelwise regression models. Plasma phosphorylated tau181 was elevated in \u03b2-amyloid positive and cognitively impaired individuals as well as in apolipoprotein E (APOE) \u03b54 carriers, and was significantly associated with age, worse cognitive performance, and CSF phosphorylated tau181. Cross-sectional analyses showed strong associations between plasma phosphorylated tau181 and [18F]FDG PET in cognitively impaired and \u03b2-amyloid positive individuals. Voxelwise longitudinal analyses showed that baseline plasma phosphorylated tau181 concentrations were significantly associated with annual rates of metabolic decline in cognitively impaired individuals, bilaterally in the medial and lateral temporal lobes. The associations between plasma phosphorylated tau181 and reduced brain metabolism, primarily in cognitively impaired and in \u03b2-amyloid positive individuals, supports the use of plasma phosphorylated tau181 as a simple, low-cost, minimally invasive, and accessible tool to both assess current and predict future metabolic dysfunction associated with Alzheimer\u2019s disease, comparatively to PET, MRI, and CSF methods.<\/p>\n<\/section>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4801","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired and Amyloid-Positive Individuals - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/plasma-levels-of-phosphorylated-tau-181-are-associated-with-cerebral-metabolic-dysfunction-in-cognitively-impaired-and-amyloid-positive-individuals-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired and Amyloid-Positive Individuals - 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