{"id":4877,"date":"2021-08-30T20:24:38","date_gmt":"2021-08-31T00:24:38","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/microglial-activation-and-tau-propagate-jointly-across-braak-stages-2\/"},"modified":"2024-12-03T14:57:55","modified_gmt":"2024-12-03T19:57:55","slug":"microglial-activation-and-tau-propagate-jointly-across-braak-stages-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/microglial-activation-and-tau-propagate-jointly-across-braak-stages-2\/","title":{"rendered":"Microglial activation and tau propagate jointly across Braak stages"},"content":{"rendered":"<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer\u2019s disease (AD). We tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain. We studied 130 individuals across the aging and AD clinical spectrum with positron emission tomography brain imaging for microglial activation ([<sup>11<\/sup>C]PBR28), amyloid-\u03b2 (A\u03b2) ([<sup>18<\/sup>F]AZD4694) and tau ([<sup>18<\/sup>F]MK-6240) pathologies. We further assessed microglial triggering receptor expressed on myeloid cells 2 (<i>TREM2<\/i>) cerebrospinal fluid (CSF) concentrations and brain gene expression patterns. We found that [<sup>11<\/sup>C]PBR28 correlated with CSF soluble TREM2 and showed regional distribution resembling\u00a0<i>TREM2<\/i>\u00a0gene expression. Network analysis revealed that microglial activation and tau correlated hierarchically with each other following Braak-like stages. Regression analysis revealed that the longitudinal tau propagation pathways depended on the baseline microglia network rather than the tau network circuits. The co-occurrence of A\u03b2, tau and microglia abnormalities was the strongest predictor of cognitive impairment in our study population. Our findings support a model where an interaction between A\u03b2 and activated microglia sets the pace for tau spread across Braak stages.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4877","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Microglial activation and tau propagate jointly across Braak stages - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/microglial-activation-and-tau-propagate-jointly-across-braak-stages-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microglial activation and tau propagate jointly across Braak stages - 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