{"id":4895,"date":"2021-10-22T19:51:09","date_gmt":"2021-10-22T23:51:09","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/association-between-regional-tau-pathology-and-neuropsychiatric-symptoms-in-aging-and-dementia-due-to-alzheimers-disease-2\/"},"modified":"2024-12-03T14:57:58","modified_gmt":"2024-12-03T19:57:58","slug":"association-between-regional-tau-pathology-and-neuropsychiatric-symptoms-in-aging-and-dementia-due-to-alzheimers-disease-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/association-between-regional-tau-pathology-and-neuropsychiatric-symptoms-in-aging-and-dementia-due-to-alzheimers-disease-2\/","title":{"rendered":"Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer\u2019s disease"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer&rsquo;s disease (AD). Here we study the relationship between NPS and AD pathologies in vivo.<\/p>\n<p><strong class=\"sub-title\">Method:\u00a0<\/strong>Two hundred and twenty-one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [<sup>18<\/sup>F]MK6240-tau-positron emission tomography (PET), [<sup>18<\/sup>F]AZD4694-amyloid-PET, magnetic resonance imaging, and neuropsychological evaluations. Spearman correlations and voxel-based regression models evaluated the relationship between Neuropsychiatric Inventory Questionnaire (NPI-Q) scores, and tau-PET, amyloid-PET, and voxel-based morphometry.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Fifty percent of individuals presented NPS; these correlated with tau, not amyloid beta or neurodegeneration. Associations between NPI-Q score and tau-PET were stronger in the parietal association area, superior frontal, temporal, and medial occipital lobes. NPI-Q domains associated with distinct patterns of tau uptake.<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>NPS are predominantly related to tau in aging and dementia. Regions affected are part of the behavioral circuits, and vulnerable to early AD pathology. Domain-specific analyses showed NPS are related to the AD pathophysiological processes in a symptom-specific manner.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4895","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer\u2019s disease - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/association-between-regional-tau-pathology-and-neuropsychiatric-symptoms-in-aging-and-dementia-due-to-alzheimers-disease-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer\u2019s disease - 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