{"id":4930,"date":"2021-12-22T20:39:04","date_gmt":"2021-12-23T01:39:04","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/regional-brain-atrophy-and-cognitive-decline-depend-on-definition-of-subjective-cognitive-decline-2\/"},"modified":"2024-12-03T14:58:04","modified_gmt":"2024-12-03T19:58:04","slug":"regional-brain-atrophy-and-cognitive-decline-depend-on-definition-of-subjective-cognitive-decline-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/regional-brain-atrophy-and-cognitive-decline-depend-on-definition-of-subjective-cognitive-decline-2\/","title":{"rendered":"Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background:\u00a0<\/strong>People with subjective cognitive decline (SCD) may be at increased risk for Alzheimer&rsquo;s disease (AD). However, not all studies have observed this increased risk. This project examined whether four common methods of defining SCD yields different patterns of atrophy and future cognitive decline between cognitively normal older adults with (SCD+ ) and without SCD (SCD-).<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>Data from 273 Alzheimer&rsquo;s Disease Neuroimaging Initiative cognitively normal older adults were examined. To operationalize SCD we used four common methods: Cognitive Change Index (CCI), Everyday Cognition Scale (ECog), ECog + Worry, and Worry. Voxel-based logistic regressions were applied to deformation-based morphology results to determine if regional atrophy between SCD- and SCD+ differed by SCD definition. Linear mixed-effects models were used to evaluate differences in future cognitive decline.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Results varied between the four methods of defining SCD. Left hippocampal grading was more similar to AD in SCD+ than SCD- when using the CCI (p = .041) and Worry (p = .021) definitions. The right (p=.008) and left (p=.003) superior temporal regions had smaller volumes in SCD+ than SCD-, but only with the ECog. SCD+ was associated with greater future cognitive decline measured by Alzheimer&rsquo;s Disease Assessment Scale, but only with the CCI definition. In contrast, only the ECog definition of SCD was associated with future decline on the Montreal Cognitive Assessment.<\/p>\n<p><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>These findings suggest that the various methods used to differentiate between SCD- and SCD+ influence whether volume differences and findings of cognitive decline are observed between groups in this retrospective analysis.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4930","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/regional-brain-atrophy-and-cognitive-decline-depend-on-definition-of-subjective-cognitive-decline-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Regional brain atrophy and cognitive decline depend on definition of subjective cognitive decline - 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