{"id":4938,"date":"2021-12-22T20:50:04","date_gmt":"2021-12-23T01:50:04","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/frailty-lifestyle-genetics-and-dementia-risk-2\/"},"modified":"2024-12-03T14:58:05","modified_gmt":"2024-12-03T19:58:05","slug":"frailty-lifestyle-genetics-and-dementia-risk-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/frailty-lifestyle-genetics-and-dementia-risk-2\/","title":{"rendered":"Frailty, lifestyle, genetics and dementia risk"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>To optimise dementia prevention strategies, we must understand the complex relationships between lifestyle behaviours, frailty and genetics.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>We explored relationships between frailty index, healthy lifestyle and polygenic risk scores (all assessed at study entry) and incident all-cause dementia as recorded on hospital admission records and death register data.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>The analytical sample had a mean age of 64.1 years at baseline (SD=2.9) and 53% were women. Incident dementia was detected in 1762 participants (median follow-up time=8.0 years). High frailty was associated with increased dementia risk independently of genetic risk (HR 3.68, 95% CI 3.11 to 4.35). Frailty mediated 44% of the relationship between healthy lifestyle behaviours and dementia risk (indirect effect HR 0.95, 95% CI 0.95 to 0.96). Participants at high genetic risk and with high frailty had 5.8 times greater risk of incident dementia compared with those at low genetic risk and with low frailty (HR 5.81, 95% CI 4.01 to 8.42). Higher genetic risk was most influential in those with low frailty (HR 1.31, 95% CI 1.22 to 1.40) but not influential in those with high frailty (HR 1.09, 95% CI 0.92 to 1.28).<\/p>\n<p><strong class=\"sub-title\">Conclusion:\u00a0<\/strong>Frailty is strongly associated with dementia risk and affects the risk attributable to genetic factors. Frailty should be considered an important modifiable risk factor for dementia and a target for dementia prevention strategies, even among people at high genetic risk.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4938","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Frailty, lifestyle, genetics and dementia risk - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/frailty-lifestyle-genetics-and-dementia-risk-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Frailty, lifestyle, genetics and dementia risk - 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