{"id":4946,"date":"2022-03-22T20:09:29","date_gmt":"2022-03-23T00:09:29","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/"},"modified":"2024-12-03T14:58:07","modified_gmt":"2024-12-03T19:58:07","slug":"cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/","title":{"rendered":"Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Background and objectives:\u00a0<\/strong>Reduced cerebrovascular reactivity is proposed to be a feature of cerebral amyloid angiopathy (CAA) but it has not been measured directly. Employing a global vasodilatory stimulus (hypercapnia) this study assessed the relationships between cerebrovascular reactivity and MRI markers of cerebral amyloid angiopathy and cognitive function.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>In a cross-sectional study design, individuals with probable cerebral amyloid angiopathy, mild cognitive impairment, dementia due to Alzheimer disease, and healthy controls underwent neuropsychological testing and an MRI that included a 5% carbon dioxide challenge. Cerebrovascular reactivity was compared across groups controlling for age, sex and the presence of hypertension, and its associations with MRI markers of cerebral amyloid angiopathy in cerebral amyloid angiopathy participants and with cognition across all participants were determined using multivariable linear regression adjusting for group, age, sex, education and the presence of hypertension.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Cerebrovascular reactivity data (mean\u00b1SD) were available for 26 participants with cerebral amyloid angiopathy (9 female; 74.4\u00b17.7y), 19 participants with mild cognitive impairment (5 female; 72.1\u00b18.5y), 12 participants with dementia due to Alzheimer disease (4 female; 69.4\u00b16.6y) and 39 healthy controls (30 female; 68.8\u00b15.4y). Grey and whiter matter reactivity averaged across the entire brain was lower in participants with cerebral amyloid angiopathy and Alzheimer disease dementia compared to healthy controls, with a predominantly posterior distribution of lower reactivity in both groups. Higher white matter hyperintensity volume was associated with lower white matter reactivity (standardized coefficient [\u03b2], 95% confidence interval): -0.48, -0.90 to -0.01. Higher gray matter reactivity was associated with better global cognitive function (\u03b2: 0.19, 0.03-0.36), memory (\u03b2: 0.21, 0.07- 0.36), executive function (\u03b2: 0.20, 0.02-0.39), and processing speed (\u03b2: 0.27, 0.10- 0.45); and higher white matter reactivity was associated with higher memory (\u03b2=0.22, 0.08-0.36) and processing speed (\u03b2=0.23, 0.06-0.40).<\/p>\n<p><strong class=\"sub-title\">Conclusions:\u00a0<\/strong>Reduced cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy, and its assessment may provide an additional biomarker for disease severity and cognitive impairment.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4946","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Background and objectives:\u00a0Reduced cerebrovascular reactivity is proposed to be ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - CCNV\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-03T19:58:07+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/CCNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cerebrovascular-reactivity-across-the-entire-brain-in-cerebral-amyloid-angiopathy-2\/\",\"name\":\"Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy - 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