{"id":4948,"date":"2022-03-22T20:11:26","date_gmt":"2022-03-23T00:11:26","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/cross-sectional-and-longitudinal-biomarker-extraction-and-analysis-for-multicentre-flair-brain-mri-2\/"},"modified":"2024-12-03T14:58:07","modified_gmt":"2024-12-03T19:58:07","slug":"cross-sectional-and-longitudinal-biomarker-extraction-and-analysis-for-multicentre-flair-brain-mri-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cross-sectional-and-longitudinal-biomarker-extraction-and-analysis-for-multicentre-flair-brain-mri-2\/","title":{"rendered":"Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI"},"content":{"rendered":"<h2 class=\"section-title u-h3 u-margin-l-top u-margin-xs-bottom\">Abstract<\/h2>\n<div id=\"abssec0010\">\n<p id=\"abspara0010\">Fluid-attenuated inversion recovery (FLAIR) MRI has emerged as an important sequence for the analysis of cerebrovascular (CVD) and Alzheimer&rsquo;s disease (AD). Large-scale, automated cross-sectional and longitudinal cerebral biomarker extraction from FLAIR datasets could progress disease characterization, improve disease monitoring, and help to determine optimal intervention times. Despite this, most automated biomarker extraction algorithms are designed for T1-weighted or multi-modal inputs. In this work, automated tools were used to extract biomarkers from large, FLAIR-only datasets to evaluate the feasibility of this sequence to characterize healthy, AD, and\u00a0<a class=\"topic-link\" title=\"Learn more about CVD from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/cerebrovascular-disease\">CVD<\/a>\u00a0subjects in a similar manner to traditional approaches. Total brain volume (TBV), cerebrospinal fluid (CSF) volume, and white matter lesion (WML) volume was measured for the cross-sectional biomarkers and the corresponding annual rates of change over multiple scans represented the longitudinal biomarkers. Biomarkers were extracted from two\u00a0<a class=\"topic-link\" title=\"Learn more about dementia from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/dementia\">dementia<\/a>\u00a0cohorts (4356\u00a0vol, 162\u00a0233 images) and one\u00a0<a class=\"topic-link\" title=\"Learn more about vascular disease from ScienceDirect's AI-generated Topic Pages\" href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/vascular-diseases\">vascular disease<\/a>\u00a0cohort (869\u00a0vol, 42\u00a0850 images) using deep learning-based segmentation algorithms designed specifically for FLAIR. Biomarkers from all cohorts were summarized using descriptive statistics, correlation analysis, and ANCOVA to assess differences in diagnostic labels while accounting for demographic and acquisition factors. Biomarkers from FLAIR MRI had similar trends with those extracted from traditional modalities in the literature for characterizing healthy, AD, and CVD subjects. This demonstrates that FLAIR MRI can be used for end-to-end analysis of large AD and CVD datasets, which can lower acquisition costs, simplify clinical translation, and reduce measurement error associated with multi-modal approaches.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[51],"class_list":["post-4948","ccna_publication","type-ccna_publication","status-publish","hentry","studies-relation-compass-nd-fr"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/cross-sectional-and-longitudinal-biomarker-extraction-and-analysis-for-multicentre-flair-brain-mri-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cross-sectional and longitudinal Biomarker extraction and analysis for multicentre FLAIR brain MRI - 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