{"id":4976,"date":"2022-03-30T16:15:19","date_gmt":"2022-03-30T20:15:19","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/white-matter-hyperintensities-and-longitudinal-cognitive-decline-in-cognitively-normal-populations-and-across-diagnostic-categories-a-meta-analysis-systematic-review-and-recommendations-for-future-2\/"},"modified":"2024-12-03T14:58:12","modified_gmt":"2024-12-03T19:58:12","slug":"white-matter-hyperintensities-and-longitudinal-cognitive-decline-in-cognitively-normal-populations-and-across-diagnostic-categories-a-meta-analysis-systematic-review-and-recommendations-for-future-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/white-matter-hyperintensities-and-longitudinal-cognitive-decline-in-cognitively-normal-populations-and-across-diagnostic-categories-a-meta-analysis-systematic-review-and-recommendations-for-future-2\/","title":{"rendered":"White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta-analysis, systematic review, and recommendations for future study harmonization"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"enc-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Introduction:\u00a0<\/strong>The primary aim of this paper is to improve the clinical interpretation of white matter hyperintensities (WMHs) and provide an overarching summary of methodological approaches, allowing researchers to design future studies targeting current knowledge gaps.<\/p>\n<p><strong class=\"sub-title\">Methods:\u00a0<\/strong>A meta-analysis and systematic review was performed investigating associations between baseline WMHs and longitudinal cognitive outcomes in cognitively normal populations, and populations with mild cognitive impairment (MCI), Alzheimer&rsquo;s disease (AD), and stroke.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Baseline WMHs increase the risk of cognitive impairment and dementia across diagnostic categories and most consistently in MCI and post-stroke populations. Apolipoprotein E (APOE) genotype and domain-specific cognitive changes relating to strategic anatomical locations, such as frontal WMH and executive decline, represent important considerations. Meta-analysis reliability was assessed using multiple methods of estimation, and results suggest that heterogeneity in study design and reporting remains a significant barrier.<\/p>\n<p><strong class=\"sub-title\">Discussion:\u00a0<\/strong>Recommendations and future directions for study of WMHs are provided to improve cross-study comparison and translation of research into consistent clinical interpretation.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4976","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta-analysis, systematic review, and recommendations for future study harmonization - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/white-matter-hyperintensities-and-longitudinal-cognitive-decline-in-cognitively-normal-populations-and-across-diagnostic-categories-a-meta-analysis-systematic-review-and-recommendations-for-future-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"White matter hyperintensities and longitudinal cognitive decline in cognitively normal populations and across diagnostic categories: A meta-analysis, systematic review, and recommendations for future study harmonization - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Introduction:\u00a0The primary aim of this paper is to improve ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/white-matter-hyperintensities-and-longitudinal-cognitive-decline-in-cognitively-normal-populations-and-across-diagnostic-categories-a-meta-analysis-systematic-review-and-recommendations-for-future-2\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - 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