{"id":4998,"date":"2022-06-30T20:48:12","date_gmt":"2022-07-01T00:48:12","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/"},"modified":"2024-12-03T14:58:16","modified_gmt":"2024-12-03T19:58:16","slug":"biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/","title":{"rendered":"Biomarker modeling of Alzheimer\u2019s disease using PET-based Braak staging"},"content":{"rendered":"<h2 id=\"Abs1\" class=\"c-article-section__title js-section-title js-c-reading-companion-sections-item\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"c-article-section__content\">\n<p>Gold-standard diagnosis of Alzheimer\u2019s disease (AD) relies on histopathological staging systems. Using the topographical information from [<sup>18<\/sup>F]MK6240 tau positron-emission tomography (PET), we applied the Braak tau staging system to 324 living individuals. We used PET-based Braak stage to model the trajectories of amyloid-\u03b2, phosphorylated tau (pTau) in cerebrospinal fluid (pTau<sub>181<\/sub>, pTau<sub>217<\/sub>, pTau<sub>231<\/sub>\u00a0and pTau<sub>235<\/sub>) and plasma (pTau<sub>181<\/sub>\u00a0and pTau<sub>231<\/sub>), neurodegeneration and cognitive symptoms. We identified nonlinear AD biomarker trajectories corresponding to the spatial extent of tau-PET, with modest biomarker changes detectable by Braak stage II and significant changes occurring at stages III\u2013IV, followed by plateaus. Early Braak stages were associated with isolated memory impairment, whereas Braak stages V\u2013VI were incompatible with normal cognition. In 159 individuals with follow-up tau-PET, progression beyond stage III took place uniquely in the presence of amyloid-\u03b2 positivity. Our findings support PET-based Braak staging as a framework to model the natural history of AD and monitor AD severity in living humans.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-4998","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Biomarker modeling of Alzheimer\u2019s disease using PET-based Braak staging - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomarker modeling of Alzheimer\u2019s disease using PET-based Braak staging - CCNA - CCNV\" \/>\n<meta property=\"og:description\" content=\"Abstract Gold-standard diagnosis of Alzheimer\u2019s disease (AD) relies on histopathological ...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/\" \/>\n<meta property=\"og:site_name\" content=\"CCNA - CCNV\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-03T19:58:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ccna-ccnv.ca\/wp-content\/uploads\/2025\/01\/CCNA.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"675\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimation du temps de lecture\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/\",\"url\":\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/biomarker-modeling-of-alzheimers-disease-using-pet-based-braak-staging-2\/\",\"name\":\"Biomarker modeling of Alzheimer\u2019s disease using PET-based Braak staging - 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