{"id":5070,"date":"2023-07-20T21:02:07","date_gmt":"2023-07-21T01:02:07","guid":{"rendered":"https:\/\/ccna-ccnv.ca\/ccna_publication\/effects-of-exercise-alone-or-combined-with-cognitive-training-and-vitamin-d-supplementation-to-improve-cognition-in-adults-with-mild-cognitive-impairment-a-randomized-clinical-trial-2\/"},"modified":"2024-12-03T14:58:28","modified_gmt":"2024-12-03T19:58:28","slug":"effects-of-exercise-alone-or-combined-with-cognitive-training-and-vitamin-d-supplementation-to-improve-cognition-in-adults-with-mild-cognitive-impairment-a-randomized-clinical-trial-2","status":"publish","type":"ccna_publication","link":"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/effects-of-exercise-alone-or-combined-with-cognitive-training-and-vitamin-d-supplementation-to-improve-cognition-in-adults-with-mild-cognitive-impairment-a-randomized-clinical-trial-2\/","title":{"rendered":"Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial"},"content":{"rendered":"<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\">Importance:\u00a0<\/strong>Exercise, cognitive training, and vitamin D may enhance cognition in older adults with mild cognitive impairment (MCI).<\/p>\n<p><strong class=\"sub-title\">Objective:\u00a0<\/strong>To determine whether aerobic-resistance exercises would improve cognition relative to an active control and if a multidomain intervention including exercises, computerized cognitive training, and vitamin D supplementation would show greater improvements than exercise alone.<\/p>\n<p><strong class=\"sub-title\">Design, setting, and participants:\u00a0<\/strong>This randomized clinical trial (the SYNERGIC Study) was a multisite, double-masked, fractional factorial trial that evaluated the effects of aerobic-resistance exercise, computerized cognitive training, and vitamin D on cognition. Eligible participants were between ages 65 and 84 years with MCI enrolled from September 19, 2016, to April 7, 2020. Data were analyzed from February 2021 to December 2022.<\/p>\n<p><strong class=\"sub-title\">Interventions:\u00a0<\/strong>Participants were randomized to 5 study arms and treated for 20 weeks: arm 1 (multidomain intervention with exercise, cognitive training, and vitamin D), arm 2 (exercise, cognitive training, and placebo vitamin D), arm 3 (exercise, sham cognitive training, and vitamin D), arm 4 (exercise, sham cognitive training, and placebo vitamin D), and arm 5 (control group with balance-toning exercise, sham cognitive training, and placebo vitamin D). The vitamin D regimen was a 10 000 IU dose 3 times weekly.<\/p>\n<p><strong class=\"sub-title\">Main outcomes and measures:\u00a0<\/strong>Primary outcomes were changes in ADAS-Cog-13 and Plus variant at 6 months.<\/p>\n<p><strong class=\"sub-title\">Results:\u00a0<\/strong>Among 175 randomized participants (mean [SD] age, 73.1 [6.6] years; 86 [49.1%] women), 144 (82%) completed the intervention and 133 (76%) completed the follow-up (month 12). At 6 months, all active arms (ie, arms 1 through 4) with aerobic-resistance exercise regardless of the addition of cognitive training or vitamin D, improved ADAS-Cog-13 when compared with control (mean difference, -1.79 points; 95% CI, -3.27 to -0.31 points; P = .02; d = 0.64). Compared with exercise alone (arms 3 and 4), exercise and cognitive training (arms 1 and 2) improved the ADAS-Cog-13 (mean difference, -1.45 points; 95% CI, -2.70 to -0.21 points; P = .02; d = 0.39). No significant improvement was found with vitamin D. Finally, the multidomain intervention (arm 1) improved the ADAS-Cog-13 score significantly compared with control (mean difference, -2.64 points; 95% CI, -4.42 to -0.80 points; P = .005; d = 0.71). Changes in ADAS-Cog-Plus were not significant.<\/p>\n<p><strong class=\"sub-title\">Conclusions and relevance:\u00a0<\/strong>In this clinical trial, older adults with MCI receiving aerobic-resistance exercises with sequential computerized cognitive training significantly improved cognition, although some results were inconsistent. Vitamin D supplementation had no effect. Our findings suggest that this multidomain intervention may improve cognition and potentially delay dementia onset in MCI.<\/p>\n<p><strong class=\"sub-title\">Trial registration:\u00a0<\/strong>ClinicalTrials.gov Identifier:\u00a0<a title=\"See in ClinicalTrials.gov\" href=\"http:\/\/clinicaltrials.gov\/show\/NCT02808676\">NCT02808676<\/a>.<\/p>\n<\/div>\n","protected":false},"author":19,"featured_media":0,"template":"","meta":{"_acf_changed":false},"studies-relation":[],"class_list":["post-5070","ccna_publication","type-ccna_publication","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial - CCNA - CCNV<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ccna-ccnv.ca\/fr\/ccna_publication\/effects-of-exercise-alone-or-combined-with-cognitive-training-and-vitamin-d-supplementation-to-improve-cognition-in-adults-with-mild-cognitive-impairment-a-randomized-clinical-trial-2\/\" \/>\n<meta property=\"og:locale\" content=\"fr_CA\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial - 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