Women, Gender, Sex and Dementia (WGSD)

Lead: Gillian Einstein

Our goal is to work with CCNA’s 20 research teams to ensure that relevant sex and gender research questions will be studied across the spectrum of neurodegeneration in both human and animal model studies.

By using this lens, CCNA’s research teams can capture important sex and gender differences in the prevalence, incidence, symptoms, and progression of neurodegenerative diseases. For example, these differences may be due to biological and physiological variations between the sexes, and/or gender differences in roles, occupations, environmental exposures, and other life experiences. Understanding sex and gender differences and how they interact is critical for developing interventions for both the prevention and treatment of neurodegeneration.


  • Creating guidelines to ensure that the data collected in Platform 1: Clinical Cohorts will enable teams to examine sex and gender differences in the 1600 cohort participants.
  • Ensuring that each sex will be equally represented in all of the neurodegenerative conditions within the Clinical Cohort.
  • Working with the teams using animal models to support the inclusion of both male and female experimental animals, to ensure generalizability of the findings to both sexes.
  • Ensuring that every CCNA publication and presentation reports sex differences in human participants, cell lines, and experimental animals (mandated through the Publications and Data Access Policy).

The Women, Gender, Sex and Dementia Cross-Cutting Program will continue to work with CCNA teams, advising and collaborating, where appropriate, to ensure the proper integration of sex and gender into their studies.

Sex and Gender Training Resources for CCNA Trainees and Researchers